TONIX ONE™ is streamlining your migraine journey by offering education, removing barriers to care, and providing savings and support resources for Zembrace® SymTouch® and Tosymra®.
TONIX ONE™ is designed to give people living with migraine the necessary resources to take action at every stage of their journey.
Non-Oral Acute Migraine Medications
Zembrace SymTouch and Tosymra are prescription medicines used to treat acute migraine headaches with or without aura in adults 18 years of age and older who have been diagnosed with migraine.
Offers the lowest, effective dose (3mg) in an easy-to-use sumatriptan autoinjector, providing significantly more patients pain freedom vs. placebo in as little as 30 minutes1:
- Simple, two-step process with the smallest2 needle ranking first3 for ease of use and administration
- You may pay as little as $0 for your Zembrace SymTouch prescription*
Tosymra’s unique formulation, including the permeation enhancer Intravail®, allows rapid and efficient absorption of sumatriptan, delivering migraine pain relief in as little as 10 minutes with just one spray4-6:
- Convenient to carry and easy to use
- You may pay as little as $0 for your Tosymra prescription*
Click on a Topic for More Information
Non-Oral Acute Migraine Medicines
Get Zembrace® SymTouch® or Tosymra®
Migraine Education & Resources
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Zembrace® SymTouch® and Tosymra®
Non-Oral Acute Migraine Medications
Zembrace SymTouch and Tosymra are prescription medicines used to treat acute migraine headaches with or without aura in adults 18 years of age and older who have been diagnosed with migraine.
Offers the lowest, effective dose (3mg) in an easy-to-use sumatriptan autoinjector, providing significantly more patients pain freedom vs. placebo in as little as 30 minutes1:
Simple, two-step process with the smallest2 needle ranking first3 for ease of use and administration
You may pay as little as $0 for your Zembrace SymTouch prescription*
Tosymra’s unique formulation, including the permeation enhancer Intravail®, allows rapid and efficient absorption of sumatriptan, delivering migraine pain relief in as little as 10 minutes with just one spray4-6:
Convenient to carry and easy to use
You may pay as little as $0 for your Tosymra prescription*
*Restrictions and quantity limits apply. Click to view complete program terms and conditions. Medicare, Medicaid, and other federal and state healthcare program patients are not eligible.
TONIX ONE Partners & Resources
Request a Prescription
from Your Doctor
ProCare PharmacyCare provides you with the ability to request a Zembrace SymTouch or Tosymra prescription from your established migraine doctor.
Just create an account, answer a few questions and they will send an e-prescription request to your doctor on your behalf. You can expect a response within 48 hours.
Schedule
an Online Visit
If you do not have an established migraine doctor or would rather use telemedicine, UpScript Health provides you with real-time access to 100’s of expert clinicians.
Simply fill out an online questionnaire and complete a visit to discuss if Zembrace SymTouch or Tosymra might be right for you.
Disease Education
Gastroparesis (GP) is common before, during, and sometimes in between migraine attacks.
GP can slow and even block the absorption of oral medication (pills), causing delayed, incomplete, or no migraine symptom relief.
Find out how Zembrace SymTouch or Tosymra can deliver medication for more reliable and faster relief from your migraine symptoms, regardless of how your stomach is functioning.
Doctor Discussion Guide
Bring this printable guide to your next appointment. This guide can be a valuable resource to your healthcare team so they fully understand the impact of migraine, associated gastroparesis (GP) and potential benefit of adding non-oral medications such as Zembrace SymTouch and Tosymra to your migraine treatment plan.
Migraine
Digital Companion
Migraine Buddy is the #1 headache and migraine tracking app. It is engineered to enhance the quality of life for those living with migraines by facilitating meticulous tracking, reporting, and self-management of symptoms, which in turn can accelerate diagnosis and fine-tune treatment options.
Migraine Disability Assessment (MIDAS)
Migraine Disability Assessment (MIDAS) is designed to measure the disease-impact of migraine on migraine-sufferers. It is a questionnaire you share with your doctor to better understand how often and how severe your migraine attacks are and is designed to estimate how much migraine gets in the way of your daily life.
Affordability & Access
Blink Health (BlinkRx) utilizes digital cutting-edge technology to provide you the best available price for Zembrace SymTouch and Tosymra with free at-home delivery. You can get your prescription for as little as $0 through BlinkRx.*
TONIX ONE Partners & Resources
Request a Prescription from Your Doctor
ProCare PharmacyCare provides you with the ability to request a Zembrace SymTouch or Tosymra prescription from your established migraine doctor.
Just create an account, answer a few questions and they will send an e-prescription request to your doctor on your behalf. You can expect a response within 48 hours.
Schedule an Online Visit
If you do not have an established migraine doctor or would rather use telemedicine, UpScript Health provides you with real-time access to 100’s of expert clinicians.
Simply fill out an online questionnaire and complete a visit to discuss if Zembrace SymTouch or Tosymra might be right for you.
Disease Education
Gastroparesis (GP) is common before, during, and sometimes in between migraine attacks.
GP can slow and even block the absorption of oral medication (pills), causing delayed, incomplete, or no migraine symptom relief.
Find out how Zembrace SymTouch or Tosymra can deliver medication for more reliable and faster relief from your migraine symptoms, regardless of how your stomach is functioning.
Doctor Discussion Guide
Bring this printable guide to your next appointment. This guide can be a valuable resource to your healthcare team so they fully understand the impact of migraine, associated gastroparesis (GP) and potential benefit of adding non-oral medications such as Zembrace SymTouch and Tosymra to your migraine treatment plan.
Migraine Digital Companion
Migraine Buddy is the #1 headache and migraine tracking app. It is engineered to enhance the quality of life for those living with migraines by facilitating meticulous tracking, reporting, and self-management of symptoms, which in turn can accelerate diagnosis and fine-tune treatment options.
Migraine Disability Assessment (MIDAS)
Migraine Disability Assessment (MIDAS) is designed to measure the disease-impact of migraine on migraine-sufferers. It is a questionnaire you share with your doctor to better understand how often and how severe your migraine attacks are and is designed to estimate how much migraine gets in the way of your daily life.
Affordability & Access
Blink Health (BlinkRx) utilizes digital cutting-edge technology to provide you the best available price for Zembrace SymTouch and Tosymra with free at-home delivery. You can get your prescription for as little as $0 through BlinkRx.*
*Restrictions and quantity limits apply. Click to view complete program terms and conditions. Medicare, Medicaid, and other federal and state healthcare program patients are not eligible.
References:
1) Landy S, et al. Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study. J Headache Pain. 2018 Aug 15;19(1):69.
2) Zembrace SymTouch [prescribing information]. Chatham, NJ: Tonix Medicines, Inc.: 2023.
3) Andre AD, et al. Subcutaneous sumatriptan delivery devices: comparative ease of use and preference among migraineurs. Patient Prefer Adherence. 2017 Jan 19;11:121-129.
4) Tosymra [prescribing information].Chatham, NJ: Tonix Medicines, Inc.: 2023.
5) Mathew NT, et al. Dose ranging efficacy and safety of subcutaneous sumatriptan in the acute treatment of migraine. US Sumatriptan Research Group. Arch Neurol. 1992;49(12):1271-1276.
6) Wendt J, et al. A randomized, double-blind, placebo-controlled trial of the efficacy and tolerability of a 4-mg dose of subcutaneous sumatriptan for the treatment of acute migraine attacks in adults. Clinical Therapeutics. 2006;28(4):517-526.
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Do not take Zembrace® SymTouch® or Tosymra® if you have hemiplegic migraines or basilar migraines or to treat cluster headache.
IMPORTANT SAFETY INFORMATION
Zembrace SymTouch or Tosymra can cause serious side effects, including heart attack and other heart problems, which may lead to death. Stop Zembrace Symtouch or Tosymra and get emergency medical help if you have any signs of heart attack:
- discomfort in the center of your chest that lasts for more than a few minutes or goes away and comes back
- severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
- pain or discomfort in your arms, back, neck, jaw or stomach
- shortness of breath with or without chest discomfort
- breaking out in a cold sweat
- nausea or vomiting
- feeling lightheaded
Zembrace and Tosymra are not for people with risk factors for heart disease (high blood pressure or cholesterol, smoking, overweight, diabetes, family history of heart disease) unless a heart exam shows no problem.
Do not use Zembrace or Tosymra if you have:
- history of heart problems
- narrowing of blood vessels to your legs, arms, stomach, or kidney (peripheral vascular disease)
- uncontrolled high blood pressure
- hemiplegic or basilar migraines. If you are not sure if you have these, ask your provider.
- had a stroke, transient ischemic attacks (TIAs), or problems with blood circulation
- severe liver problems
- taken any of the following medicines in the last 24 hours: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, ergotamines, or dihydroergotamine. Ask your provider for a list of these medicines if you are not sure.
- are taking certain antidepressants, known as monoamine oxidase (MAO)-A inhibitors or it has been 2 weeks or less since you stopped taking a MAO-A inhibitor. Ask your provider for a list of these medicines if you are not sure.
- an allergy to sumatriptan or any of the components of Zembrace or Tosymra
Tell your provider about all of your medical conditions and medicines you take, including vitamins and supplements.
Zembrace and Tosymra can cause dizziness, weakness, or drowsiness. If so, do not drive a car, use machinery, or do anything where you need to be alert.
Zembrace and Tosymra may cause serious side effects including:
- changes in color or sensation in your fingers and toes
- sudden or severe stomach pain, stomach pain after meals, weight loss, nausea or vomiting, constipation or diarrhea, bloody diarrhea, fever
- cramping and pain in your legs or hips; feeling of heaviness or tightness in your leg muscles; burning or aching pain in your feet or toes while resting; numbness, tingling, or weakness in your legs; cold feeling or color changes in one or both legs or feet
- increased blood pressure including a sudden severe increase even if you have no history of high blood pressure
- medication overuse headaches from using migraine medicine for 10 or more days each month. If your headaches get worse, call your provider.
- serotonin syndrome, a rare but serious problem that can happen in people using Zembrace or Tosymra, especially when used with anti-depressant medicines called SSRIs or SNRIs. Call your provider right away if you have: mental changes such as seeing things that are not there (hallucinations), agitation, or coma; fast heartbeat; changes in blood pressure; high body temperature; tight muscles; or trouble walking.
- hives (itchy bumps); swelling of your tongue, mouth, or throat
- seizures even in people who have never had seizures before
The most common side effects of Zembrace and Tosymra include: pain and redness at injection site (Zembrance only); tingling or numbness in your fingers or toes; dizziness; warm, hot, burning feeling to your face (flushing); discomfort or stiffness in your neck; feeling weak, drowsy, or tired; application site (nasal) reactions (Tosymra only) and throat irritation (Tosymra only).
Tell your provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of Zembrace and Tosymra. For more information, ask your provider.
This is the most important information to know about Zembrace and Tosymra but is not comprehensive. For more information, talk to your provider and read the Patient Information and Instructions for Use. You can also visit https://www.tonixpharma.com or call 1-888-869-7633.
You are encouraged to report adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.